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Trends Biochem Sci. 1998 Jan;23(1):20-5.

Chromatin remodeling machines: similar motors, ulterior motives.

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Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.


Chromatin is a dynamic material; chromatin structures can repress transcription and their remodeling accompanies activation. Recent biochemical studies in Drosophila have revealed three multi-protein complexes with ATP-dependent chromatin restructuring activities. Although all contain the ATPase ISWI, their properties in vitro are markedly different, distinct from SWI-SNF and reveal intriguing connections to both transcription and chromatin assembly.

[Indexed for MEDLINE]

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