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Trends Biochem Sci. 1998 Jan;23(1):10-4.

The endoplasmic reticulum Ca2+ store: a view from the lumen.

Author information

1
Department of Pharmacology, B. Ceccarelli Center of Neurobiology, University of Milano, Italy.

Abstract

The endoplasmic reticulum (ER) and its specialized subcompartments such as the sarcoplasmic reticulum, is the main dynamic Ca2+ storage compartment of the cell. Key cellular functions are regulated, either directly or indirectly, by the free Ca2+ concentration in the ER. This article discusses the properties of Ca2+ storage in the ER and considers the functions that appear to be regulated by the Ca2+ stores within the ER, both in and around the ER and at a distance from it.

PMID:
9478128
[Indexed for MEDLINE]

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