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Trends Biochem Sci. 1998 Jan;23(1):4-9.

Triplex-directed modification of genes and gene activity.

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Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA.


Oligonucleotides offer enormous potential for manipulating gene function in cells and, as such, constitute a promising new class of pharmaceutical agents. Oligonucleotides that form triple helices (triplexes) at specific DNA sequences in defined genes can be used to reduce transcription selectively, to introduce site-specific mutations or to stimulate gene-specific targeted recombination.

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