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J Am Coll Nutr. 1998 Feb;17(1):75-8.

Effects of captopril and enalapril on zinc metabolism in hypertensive patients.

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1
Department of Internal Medicine A, Assaf Harofeh Medical Center, Zerifin, Israel.

Abstract

OBJECTIVE:

To investigate the effect of chronic captopril and enalapril treatment on zinc metabolism in hypertensive patients by assessing zinc levels in serum, urine and monocytes.

METHODS:

Patients with newly diagnosed essential hypertension were randomly divided into two treatment groups: those treated with captopril only (n = 16) and those treated with enalapril only (n = 18). Ten healthy subjects served as controls. Prior to the start of treatment and again 6 months later, zinc was assessed in the serum, in urine collected over 24 hours, and in peripheral blood monocytes.

RESULTS:

Significant enhancement of 24-hour urinary zinc excretion (micrograms/24 hour) after 6 months of treatment was observed only in the captopril-treated group (p < 0.01). However, intramonocytic zinc levels decreased significantly in both of the treated groups over the same period (p < 0.01 and P < 0.04 in the captopril- and enalapril-treated groups, respectively).

CONCLUSION:

Treatment of hypertensive patients with captopril or enalapril may result in zinc deficiency.

PMID:
9477394
[Indexed for MEDLINE]

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