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Cancer Gene Ther. 1998 Jan-Feb;5(1):3-28.

Suppression of growth and transformation and induction of apoptosis by EGR-1.

Author information

1
Sidney Kimmel Cancer Center, San Diego, California 92121, USA.

Abstract

Although cloned as an "immediate-early gene," recent studies show that EGR-1 functions in growth regulation and suppression of transformation by transactivation of the transforming growth factor beta-1 (TGF-beta1) gene and cooperation with Sp1, Jun-B, p21WAF1/Cip1, and stimulates apoptosis by transactivation of the p53 gene.

PMID:
9476963
[Indexed for MEDLINE]

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