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Immunol Rev. 1997 Dec;160:63-77.

Immunosenescence and germinal center reaction.

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Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201-1559, USA.


Dysfunction of the immune system in aged individuals includes at least two important factors: accumulation of immunocytes with reduced function and accumulation of lymphocyte clones with self-reactive potential. Coincidently, there is a profound reduction of the germinal center reaction in the aged. While this reduction is likely the result of age-associated impairment in lymphocyte function (e.g. diminished response to costimulus, altered lymphokine production etc.), the reduction of germinal centers may itself make an important contribution to further immunological dysfunction.

[Indexed for MEDLINE]

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