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Doc Ophthalmol. 1996-1997;92(4):253-67.

Assessing abnormal rod photoreceptor activity with the a-wave of the electroretinogram: applications and methods.

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1
Department of Psychology, Columbia University, New York, NY, USA. don@psych.Columbia.edu

Abstract

The impact of a disease on phototransduction can be assessed by fitting the leading edge of the rod a-wave to high-energy flashes with a quantitative expression. Two parameters of rod receptor activity are obtained, S (sensitivity) and Rm (maximum response). In this study, the meaning of these parameters and examples of conditions that change them were examined. In addition, a new protocol was developed for obtaining these parameters. A set of three to five white flashes were first presented in the dark and then on an adapting field (30 cd/m2). Subtracting the light-adapted responses from the dark-adapted responses yielded isolated rod a-wave responses. A clinical protocol was developed based on a single white flash energy. It is possible to determine whether a disease is producing a change in S and/or Rm with this single flash energy without the use of any equations.

PMID:
9476593
[Indexed for MEDLINE]
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