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J Reprod Med. 1998 Jan;43(1):3-10.

hCG, its free subunits and its metabolites. Roles in pregnancy and trophoblastic disease.

Author information

1
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

OBJECTIVE:

To examine the structure and metabolism of human chorionic gonadotropin (hCG) and the effect of molecular heterogeneity on the immunodiagnosis and monitoring of gestational trophoblastic disease.

STUDY DESIGN:

A review of the current medical literature concerning measurement of hCG and hCG-related molecules.

RESULTS:

hCG molecules in gestational trophoblastic disease are more heterogeneous or degraded in serum and urine samples than in normal pregnancy.

CONCLUSION:

Appropriate measurement and monitoring of hCG levels in gestational trophoblastic disease require an understanding of hCG structure and metabolism.

PMID:
9475142
[Indexed for MEDLINE]

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