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Brain Res. 1998 Jan 1;779(1-2):359-63.

Nicotinic alpha 7 receptors protect against glutamate neurotoxicity and neuronal ischemic damage.

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1
Department of Neurology, Faculty of Medicine, Kyoto University, Japan.

Abstract

The alpha7 receptor agonist dimethoxybenzylidene anabaseine (DMXB) protected rat neocortical neurons against excitotoxicity administered 24 h before, but not concomitantly with, NMDA. This action was blocked by nicotinic but not muscarinic antagonists. DMXB (1 mg/kg i.p.) also reduced infarct size in rats when injected 24 h before, but not during, focal ischemic insults. In a mecamylamine-sensitive manner, alpha7 receptors appear neuroprotective in non-apoptotic model.

PMID:
9473725
[Indexed for MEDLINE]
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