Format

Send to

Choose Destination
Biochem Biophys Res Commun. 1998 Feb 4;243(1):86-9.

Interactions of drebrin and gephyrin with profilin.

Author information

1
Department of Molecular Biology and Biochemistry, Osaka University Medical School, Suita, Japan.

Abstract

Profilin is an actin monomer-binding protein which stimulates actin polymerization. Recent studies have revealed that profilin interacts with VASP, Mena, Bnilp, Bnrlp, and mDia, all of which have the proline-rich domain. Here, we isolated three profilin-binding proteins from rat brain cytosol by glutathione S-transferase-profilin affinity column chromatography and identified them as Mena, drebrin, and gephyrin. These proteins had a proline-rich domain and directly interacted with profilin.

PMID:
9473484
DOI:
10.1006/bbrc.1997.8068
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center