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Clin Immunol Immunopathol. 1998 Feb;86(2):121-33.

Gammadelta T cells in host defense and epithelial cell biology.

Author information

1
The Scripps Research Institute, La Jolla, California 92037, USA.

Abstract

Recent studies have demonstrated increased numbers of gammadelta T cells in a variety of human infectious as well as noninfectious diseases. In some cases gammadelta T cells could be shown to destroy infected or transformed cells. Advances in the identification of ligands recognized by gammadelta T cells and the development of animal model systems to study these cells in vivo should overcome some of the major obstacles currently preventing a better understanding of gammadelta T cell function in immune responses. As we gain this knowledge it may become possible to design therapeutic strategies exploiting unique properties of gammadelta T cells to promote more effective immunity.

PMID:
9473374
[Indexed for MEDLINE]

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