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Biol Reprod. 1998 Jan;58(1):152-9.

Infertility in mice induced by a recombinant ectromelia virus expressing mouse zona pellucida glycoprotein 3.

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  • 1Commonwealth Scientific Industrial Research Organisation, Division of Wildlife and Ecology, Australian National University, Canberra, ACT. r.jackson@dwe.csiro.au

Abstract

Population control has become a major problem in many wildlife species. Fertility control through immunocontraception has been proposed as a method for reducing population size. We have tested the concept that immunocontraception can be achieved with a recombinant ectromelia virus expressing an ovary-specific antigen, the mouse zona pellucida 3 (ZP3) glycoprotein. Female mice infected with the recombinant virus produced autoimmune antibodies against ZP3 and were infertile for 5-9 mo after infection. For almost half the infertile mice, immunity to ZP3 was associated with a disruption of ovarian follicular development and the depletion of mature follicles without observable oophoritis. Mice returned to fertility as the anti-ZP3 antibody level in the serum decreased. Reinfection of the mice with the recombinant virus boosted the anti-ZP3 response and restored infertility.

PMID:
9472936
[PubMed - indexed for MEDLINE]
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