Localization of the pathological structures in relation to the surrounding anatomy and understanding of the surgical anatomy are probably the most important keys to successful neurosurgery. Image-guided surgery is an important tool for understanding an individual's anatomy and for precisely locating the lesion. Head registration is the most important step in image-guided surgery, required by every system in use today, although these systems show great differences. In this study, head registration techniques and user algorithms in 83 image-guided surgery cases were analyzed. Several types of fiducials including skin markers, bone fiducials, and the stereotactic frame were used for registration. Clinical applications, ease of use, and computer-calculated accuracy values for each type were compared. The average accuracy was 1.50 mm. X-spot skin markers are the fiducials most commonly used with CT scan. The stereotactic frame was the most accurate method, with an accuracy of 0.69 mm. Disc-shaped fiducials were used when MRI was the imaging modality; they provided an average accuracy of 2.62 mm. Head registration is an important part of image-guided surgery; the procedure used for registration should be based on the requirements of each individual case. Our results indicated that the stereotactic frame is the most accurate method of registration; however, skin markers provide reasonable accuracy with significant ease of use and patient comfort.