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Trends Biotechnol. 1998 Jan;16(1):35-40.

Viral vectors for gene therapy.

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Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA.


Gene therapy is now being applied to the treatment of wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes-simplex viruses and adeno-associated viruses. These viral vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.

[Indexed for MEDLINE]

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