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Trends Biotechnol. 1998 Jan;16(1):35-40.

Viral vectors for gene therapy.

Author information

1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, PA 15261, USA. probb@pop.pitt.edu

Abstract

Gene therapy is now being applied to the treatment of wide variety of acquired and inherited diseases. One of the rate-limiting steps for successful gene therapy is the efficiency of gene transfer. A number of different viral systems are being developed for use as vectors for ex vivo and in vivo gene transfer, including retroviruses, adenoviruses, herpes-simplex viruses and adeno-associated viruses. These viral vectors have a number of specific advantages and disadvantages that make them suited to particular gene-therapeutic applications. This review will summarize the current status of the development of viral vectors for gene therapy.

PMID:
9470229
DOI:
10.1016/S0167-7799(97)01137-2
[Indexed for MEDLINE]

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