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FEBS Lett. 1998 Jan 16;421(3):277-9.

Resveratrol, a remarkable inhibitor of ribonucleotide reductase.

Author information

1
Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Grenoble, France. Fontecav@cbcrb.ceng.cea.fr

Abstract

Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

PMID:
9468322
DOI:
10.1016/s0014-5793(97)01572-x
[Indexed for MEDLINE]
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