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FEBS Lett. 1998 Jan 9;421(2):159-64.

MT1-MMP on the cell surface causes focal degradation of gelatin films.

Author information

1
INSERM U296, Faculté de Médecine, Créteil, France.

Abstract

The membrane-type matrix metalloproteinases (MT-MMPs) are a subclass of the matrix metalloproteinase (MMP) family which uniquely possess a C-terminal transmembrane domain and are initiators of an activation cascade for progelatinase A (MMP-2). Recent studies have shown that they can also efficiently directly degrade a number of matrix macromolecules. We now show that cells expressing MT1-MMP on their cell surfaces cause subjacent proteolysis of a gelatin film and that this proteolysis is inhibited by TIMP-2 but not by TIMP-1. These data indicate that expression of MT1-MMP on the cell surface may lead to both progelatinase A activation and extracellular matrix degradation.

PMID:
9468298
DOI:
10.1016/s0014-5793(97)01555-x
[Indexed for MEDLINE]
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