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Trends Neurosci. 1998 Jan;21(1):2-7.

Calcium and neuronal ageing.

Author information

1
Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany.

Abstract

Brain ageing is associated with a marked decline in mental faculties. One hypothesis postulates that sustained changes in the regulation of intracellular Ca2+ concentration, [Ca2+]i, are the major cause of neuronal degeneration. This 'calcium hypothesis' is supported by demonstrations of the impairment in aged neurones of molecular cascades that regulate [Ca2+]i. However, the number of direct measurements of [Ca2+]i in senescent neurones is limited, and the hypothesis cannot be regarded as fully confirmed. Furthermore, physiological brain ageing, at least in certain regions, need not necessarily be a degenerative process accompanied by neuronal loss. Pharmacological manipulation of Ca2+ entry has been shown to be effective in increasing some aspects of cognitive function of the aged brain. Therefore, further exploration of Ca2+ homeostasis and signalling might reveal the mechanisms involved in the age-dependent decline in neuronal performance, and might aid the search for new therapeutic treatments.

PMID:
9464677
DOI:
10.1016/s0166-2236(97)01156-9
[Indexed for MEDLINE]

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