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Neurosci Lett. 1997 Dec 5;238(3):135-8.

Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells.

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1
Molecular Biology and Biophysics Group, King's College London, Strand, UK.

Abstract

Malondialdehyde (MDA) is a deleterious end-product of lipid peroxidation. The naturally-occurring dipeptide carnosine (beta-alanyl-L-histidine) is found in brain and innervated tissues at concentrations up to 20 mM. Recent studies have shown that carnosine can protect proteins against cross-linking mediated by aldehyde-containing sugars and glycolytic intermediates. Here we have investigated whether carnosine is protective against malondialdehyde-induced protein damage and cellular toxicity. The results show that carnosine can (1) protect cultured rat brain endothelial cells against MDA-induced toxicity and (2) inhibit MDA-induced protein modification (formation of cross-links and carbonyl groups).

PMID:
9464638
[Indexed for MEDLINE]

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