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Kidney Int. 1998 Feb;53(2):282-6.

A locus for inherited focal segmental glomerulosclerosis maps to chromosome 19q13.

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Department of Medicine, Oklahoma State University College of Osteopathic Medicine, Tulsa, USA.


We performed a genome-wide linkage analysis search for a genetic locus responsible for kidney dysfunction in a large family. This inherited condition, characterized by proteinuria, progressive renal insufficiency, and focal segmental glomerulosclerosis, follows autosomal dominant inheritance. We show with a high degree of certainty (maximum 2-point lod score 12.28) that the gene responsible for this condition is located on chromosome 19q13.

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