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Trends Pharmacol Sci. 1997 Dec;18(12):474-83.

The real life of voltage-gated K+ channels: more than model behaviour.

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  • 1Department of Biochemistry, Imperial College, London, UK.


The past ten years have provided an embarrassment of riches for those interested in cloned voltage-gated K+ (Kv) channels. Details of their physiology and pharmacology in expression systems, and their precise cellular location abound, making them excellent targets for pharmacologists. However, there is still a considerable and important gap in our knowledge between the behaviour of expressed Kv channels and K+ currents in vivo. In this review Brian Robertson focuses on a few of the recent developments in the field of Kv channels, namely modulation of their behaviour by accessory subunits, their control, and localization of identified Kv subunits.

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