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Int J Oncol. 1998 Feb;12(2):309-13.

Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues.

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Department of Pathology, Uppsala University Hospital, S-751 85 Uppsala, Sweden.


We investigated the mRNA expression of the human endogenous retrovirus ERV3 (HERV-R) in several normal and corresponding tumor tissues. The env gene of ERV3 is expressed as mRNA in several tissues. Comparison of ERV3 mRNA expression by Northern analyses, revealed a non-systematic variation. Expression was shown to be particularly high in the adrenal gland and some cases of lung cancer. This tissue-tropism should be seen in relation to the high expression previously found in syncytiotrophoblasts in placenta and sebaceous glands of the skin, suggesting profound influences by steroid hormonal regulation.

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