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Eur J Pharmacol. 1997 Nov 5;338(2):R3-5.

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation.

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Pfizer Inc., Department of Neuroscience, Groton, CT 06340, USA.


Clozapine (1-10 mg/kg s.c.) produces a selective increase in dopamine release in rat prefrontal cortex which is, in large part (approximately 50%), mediated via activation of 5-HT1A receptors. Clozapine is a moderately potent, partial 5-HT1A receptor agonist and activation of 5-HT1A receptors may contribute to its efficacy against negative symptoms and reduced extrapyramidal side effect liability. Agonist affinity for 5-HT1A receptors could thus be a desirable feature in the design of new antipsychotics.

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