Format

Send to

Choose Destination
See comment in PubMed Commons below
Eur J Pharmacol. 1997 Nov 5;338(2):R3-5.

Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation.

Author information

1
Pfizer Inc., Department of Neuroscience, Groton, CT 06340, USA. hans_rollema@groton.pfizer.com

Abstract

Clozapine (1-10 mg/kg s.c.) produces a selective increase in dopamine release in rat prefrontal cortex which is, in large part (approximately 50%), mediated via activation of 5-HT1A receptors. Clozapine is a moderately potent, partial 5-HT1A receptor agonist and activation of 5-HT1A receptors may contribute to its efficacy against negative symptoms and reduced extrapyramidal side effect liability. Agonist affinity for 5-HT1A receptors could thus be a desirable feature in the design of new antipsychotics.

PMID:
9456005
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center