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[Pregnancy after heart and heart-lung transplantation. Apropos of 10 cases and review of the literature].

[Article in French]

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1
Service de Gynécologie-Obstétrique, Hôpital Antoine-Béclère, Clamart.

Abstract

INTRODUCTION:

A survey of all French Centres performing heart and heart lung transplant provided an exhaustive registry of pregnancy after transplantation.

MATERIAL AND METHODS:

A questionnaire was sent to 36 Centres. Anonymous reports of transplantation and subsequent pregnancies which occurred between 1984 and 1994 were analyzed.

RESULTS:

Among 1290 heart and 120 heart lung transplantations performed during the study period 10 pregnancies were reported in 9 patients (6 after heart transplantation and 3 heart-lung transplantation) who gave birth to 11 neonates. The interval between the transplantation and the pregnancy is 23.1 months (range: 10-39). High blood pressure complicated nine pregnancies and severe preeclampsia occurred in two cases. Immunosuppressive therapy was i) Cyclosporine alone (n = 1), ii) i with corticosteroid therapy (n = 7), iii) ii with azathioprine (n = 2). One patient developed Kaposi sarcoma of the cervix. Delivery at 35 (27-39) weeks' gestation was by caesarean section in 50% of the cases. Mean birthweight was 1990 gm (range: 700-2880) and 50% of the neonates were below the tenth centile. One child developed cardiomyopathy as diagnosed in her mother and another one was diagnosed with congenital hepatitis B by absence of prophylaxis at birth. All the patients are alive at this time.

PMID:
9453976
[Indexed for MEDLINE]
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