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EMBO J. 1998 Feb 2;17(3):667-76.

AIM-1: a mammalian midbody-associated protein required for cytokinesis.

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1
Louis Pasteur Center for Medical Research, Department of Molecular Biology, 103-5 Tanaka Monzencho, Sakyo-ku, Kyoto 606. terada@fas.harvard.edu

Abstract

Mitosis is a highly coordinated process that assures the fidelity of chromosome segregation. Errors in this process result in aneuploidy which can lead to cell death or oncogenesis. In this paper we describe a putative mammalian protein kinase, AIM-1 (Aurora and Ipl1-like midbody-associated protein), related to Drosophila Aurora and Saccharomyces cerevisiae Ipl1, both of which are required for chromosome segregation. AIM-1 message and protein accumulate at G2/M phase. The protein localizes at the equator of central spindles during late anaphase and at the midbody during telophase and cytokinesis. Overexpression of kinase-inactive AIM-1 disrupts cleavage furrow formation without affecting nuclear division. Furthermore, cytokinesis frequently fails, resulting in cell polyploidy and subsequent cell death. These results strongly suggest that AIM-1 is required for proper progression of cytokinesis in mammalian cells.

PMID:
9450992
PMCID:
PMC1170416
DOI:
10.1093/emboj/17.3.667
[Indexed for MEDLINE]
Free PMC Article
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