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J Exp Med. 1998 Feb 2;187(3):439-44.

Interleukin 10 increases CCR5 expression and HIV infection in human monocytes.

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1
Istituto di Ricerche Farmacologiche 'Mario Negri', 20157 Milan, Italy.

Abstract

The immunosuppressive and antiinflammatory cytokine interleukin (IL) 10 selectively upregulates the expression of the CC chemokine receptors CCR5, 2, and 1 in human monocytes by prolonging their mRNA half-life. IL-10-stimulated monocytes display an increased number of cell surface receptors for, and better chemotactic responsiveness to, relevant agonists than do control cells. In addition, IL-10-stimulated monocytes are more efficiently infected by HIV BaL. This effect was associated to the enhancement of viral entry through CCR5. These data add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.

PMID:
9449724
PMCID:
PMC2212126
[Indexed for MEDLINE]
Free PMC Article
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