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Eur J Surg. 1997 Dec;163(12):923-8.

Surgical treatment of hepatic hydatidosis combined with perioperative treatment with albendazole.

Author information

1
Department of General Surgery, Ankara University Medical School, Turkey.

Abstract

OBJECTIVE:

To evaluate the effect of albendazole combined with surgery on the incidence of recurrent hydatid disease.

DESIGN:

Prospective open study.

SETTING:

Teaching hospital, Turkey.

SUBJECTS:

25 patients who presented with hepatic hydatid disease between December 1992 and October 1995.

INTERVENTIONS:

Albendazole 10 mg/kg/day for a month before ultrasonography and then excision, and then albendazole for a further two months.

RESULTS:

2 patients were excluded because the albendazole caused disturbance of liver enzyme activities. Of the remaining 23 patients only 7 had viable cysts on ultrasonography. In 15 patients (65%) the germinal layer was partially or totally destroyed, and in 15 the fluid was either cloudy or stained with bile. During a mean follow up period of 29 months only one patient developed recurrent disease.

CONCLUSION:

Perioperative treatment with albendazole resulted in fewer recurrences than expected. A longer preoperative period of treatment may increase the success rate; this requires further study.

PMID:
9449445
[Indexed for MEDLINE]

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