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Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1218-23.

Basic fibroblast growth factor induces cell migration and proliferation after glia-specific gene transfer in mice.

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Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.


Basic fibroblast growth factor (bFGF) is overexpressed in most high-grade human gliomas, implying that it is involved in the pathogenesis of these tumors. To assess the biological effect of inappropriate production of bFGF in normal astrocytes, we developed a system for glia-specific gene transfer in transgenic mice. A transgene encoding the receptor for subgroup A avian leukosis virus and controlled by the astrocyte-specific glial fibrillary acidic protein promoter permits efficient glia-specific transfer of genes carried by subgroup A avian leukosis virus vectors. With this system, we have demonstrated that bFGF induces proliferation and migration of glial cells in vivo, without the induction of tumors.

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