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J Am Acad Dermatol. 1998 Jan;38(1):21-6.

Low-dose UVA phototherapy for treatment of localized scleroderma.

Author information

1
Department of Dermatology, Ruhr-University Bochum, Germany.

Abstract

BACKGROUND:

For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success.

OBJECTIVE:

We attempted to determine the efficacy of low-dose UVA1 irradiation in patients with severe localized scleroderma.

METHODS:

Patients were irradiated with 20 J/cm2 UVA1 for 12 weeks (total number of treatments: 30; cumulative UVA1 dose: 600 J/cm2).

RESULTS:

Low-dose UVA1 irradiation induced significant clinical improvement (clearance of > 80% of lesions) in 18 of 20 patients. Clearance was documented by clinical score as well as by 20 MHz ultrasound and histopathologic analysis.

CONCLUSION:

Low-dose UVA1 phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy.

Comment in

PMID:
9448200
DOI:
10.1016/s0190-9622(98)70533-x
[Indexed for MEDLINE]

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