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Proteins. 1998 Jan;30(1):49-60.

Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides.

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Freie Universität Berlin, Universitätsklinikum Benjamin Franklin, Institut für Medizinische/Technische Physik und Lasermedizin, AG Molekulare Bioinformatik, Germany.


Cleavage sites in nuclear-encoded mitochondrial protein targeting peptides (mTPs) from mammals, yeast, and plants have been analysed for characteristic physicochemical features using statistical methods, perceptrons, multilayer neural networks, and self-organizing feature maps. Three different sequence motifs were found, revealing loosely defined arginine motifs with Arg in positions -10, -3, and -2. A self-organizing feature map was able to cluster these three types of endopeptidase target sites but did not identify any species-specific characteristics in mTPs. Neural networks were used to define local sequence features around precursor cleavage sites.

[Indexed for MEDLINE]

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