Format

Send to

Choose Destination
Proteins. 1998 Jan;30(1):49-60.

Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides.

Author information

1
Freie Universität Berlin, Universitätsklinikum Benjamin Franklin, Institut für Medizinische/Technische Physik und Lasermedizin, AG Molekulare Bioinformatik, Germany.

Abstract

Cleavage sites in nuclear-encoded mitochondrial protein targeting peptides (mTPs) from mammals, yeast, and plants have been analysed for characteristic physicochemical features using statistical methods, perceptrons, multilayer neural networks, and self-organizing feature maps. Three different sequence motifs were found, revealing loosely defined arginine motifs with Arg in positions -10, -3, and -2. A self-organizing feature map was able to cluster these three types of endopeptidase target sites but did not identify any species-specific characteristics in mTPs. Neural networks were used to define local sequence features around precursor cleavage sites.

PMID:
9443340
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center