Format

Send to

Choose Destination
Annu Rev Genet. 1997;31:91-111.

Gene amplification and genomic plasticity in prokaryotes.

Author information

1
Department of Molecular Genetics, National University of Mexico, Cuernavaca, Morelos, Mexico. dromero@cifn.unam.mx

Abstract

Gene amplification is a common feature of the genome of prokaryotic organisms. In this review, we analyze different instances of gene amplification in a variety of prokaryotes, including their mechanisms of generation and biological role. Growing evidence supports the concept that gene amplification be considered not as a mutation but rather as a dynamic genomic state related to the adaptation of bacterial populations to changing environmental conditions or biological interactions. In this context, the potentially amplifiable DNA regions impose a defined dynamic structure on the genome. If such structure has indeed been selected during evolution, it is a particularly challenging hypothesis.

PMID:
9442891
DOI:
10.1146/annurev.genet.31.1.91
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center