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Ann Intern Med. 1998 Jan 15;128(2):111-4.

Serious hepatitis A: an analysis of patients hospitalized during an urban epidemic in the United States.

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1
University of Tennessee, Memphis 38163, USA.

Abstract

BACKGROUND:

Memphis and Shelby County, Tennessee, experienced an epidemic of hepatitis A in 1994 and 1995. More than 1700 cases were reported.

OBJECTIVE:

To characterize the clinical features of patients hospitalized during a large urban epidemic of hepatitis A.

DESIGN:

Retrospective chart review.

SETTING:

15 acute care hospitals in Shelby County, Tennessee.

PATIENTS:

256 patients hospitalized with acute hepatitis A.

MEASUREMENTS:

Laboratory findings (such as prothrombin time and bilirubin level), complications, and mortality.

RESULTS:

The median patient age was 26 years. Thirty-nine complications occurred in 35 patients. Twenty patients (8%) had extrahepatic complications, and 5 (2%) died. Patients 40 years of age and older were more likely to have serious complications, including death (P = 0.014). Sixty-seven patients (26%) presented with coagulopathy (prothrombin time > or = 3 seconds prolonged). Fifty-four patients (21%) had a bilirubin level greater than 170 micromol/L (10 mg/dL).

CONCLUSIONS:

During this epidemic, hepatitis A caused serious illness and death. Complications were more frequent in patients 40 years of age and older, but young, healthy persons were also at risk for severe complications.

PMID:
9441570
[Indexed for MEDLINE]

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