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Rev Med Brux. 1997 Oct;18(5):323-7.

[Febrile neutropenia: empiric antibiotic therapy from 1975 to 1997].

[Article in French]

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Service de Médecine Interne, Institut Jules Bordet, Université Libre de Bruxelles.


Monotherapy with ceftazidime, cefepime, imipenem or meropenem for the empiric treatment of febrile neutropenia appears as effective as the combination therapy involving aminoglycosides. However, empiric therapy with a combination of a beta-lactam plus an aminoglycoside is a reasonable decision under circumstances where Gram negative sepsis is very likely. Monotherapy is usually associated with a modest rate of response in infections caused by Gram positive organisms. In about 30% of the patients, a glycopeptide will be added at some point, because the response to the initial therapy is not considered optimal.

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