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Int J Tuberc Lung Dis. 1997 Feb;1(1):12-5.

Should ethambutol be recommended for routine treatment of tuberculosis in children? A review of the literature.

Author information

1
International Union Against Tuberculosis and Lung Disease, Paris, France.

Abstract

SETTING:

Review of the literature referenced from Medline and other sources on the use of ethambutol in children.

OBJECTIVE:

The most well-known side effect of ethambutol is its ocular toxicity. Its use among children is thus generally discouraged. The present article summarizes the studies published on this subject.

RESULTS:

No authors have reported major ocular side effects among children treated with ethambutol.

CONCLUSION:

For children aged 5 years or more, ethambutol can be recommended at a dosage of 15 mg/kg/day for routine treatment, without taking more precautions than for adults; this should be included in official recommendations. For younger children, ethambutol can also be used without undue fear of side-effects.

PMID:
9441051
[Indexed for MEDLINE]

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