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Arch Surg. 1998 Jan;133(1):32-5.

Efficacy of a dry fibrin sealant dressing for hemorrhage control after ballistic injury.

Author information

1
Department of Surgery, William Beaumont Army Medical Center, El Paso, Tex, USA.

Abstract

OBJECTIVE:

To determine if a dry fibrin sealant dressing (DFSD) will provide superior hemostasis when compared with regular gauze in a ballistic injury animal model.

DESIGN:

A nonsurvival randomized goat study.

SETTING:

A federal biomedical research institute.

SUBJECTS:

Eighteen anesthetized Angora goats.

INTERVENTIONS:

Uncontrolled hemorrhage was induced by a complex ballistic extremity injury. Control of hemorrhage was achieved by applying and holding pressure with the DFSD or regular gauze for 2 minutes. The dressings were left in place for 1 hour.

MAIN OUTCOME MEASURES:

Total blood loss, mean arterial pressure, ballistic injury, and mortality were recorded after 1 hour.

RESULTS:

The injuries were equivalent for the 2 groups. No animal mortality was seen. After 1 hour, the mean (+/-SEM) blood loss was 124+/-64 mL in the DFSD-treated group and 377+/-64 mL in the gauze dressings-treated group (P=.01). Twenty minutes after injury, the mean arterial pressure was 95.0 mm Hg (+/-SEM, +/-4.7 mm Hg) in the DFSD-treated group and 70.0+/-5.0 mm Hg in the gauze dressings-treated group. The difference persisted for the remainder of the study (P=.01).

CONCLUSION:

The DFSD was superior to gauze in decreasing blood loss and maintaining blood pressure while retaining the simplicity of standard dressing application.

PMID:
9438755
[Indexed for MEDLINE]

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