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Vet Immunol Immunopathol. 1997 Oct 6;59(1-2):11-20.

Establishment and characterization of a canine T-lymphoblastoid cell line derived from malignant lymphoma.

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Department of Veterinary Internal Medicine, Faculty of Agriculture, University of Tokyo, Japan.


A canine lymphoma cell line (CL-1) was established in culture from tumor cells found in the pleural fluid of a 7-year old female Japanese terrier with thymic form lymphoma. The CL-1 cells were positive for CD45 and MHC class II and negative for CD4, CD5, CD8, Thy-1 and B-cell specific antigen and surface immunoglobulin. The CL-1 cells had a rearranged T-cell receptor beta-chain gene and a germ-line form immunoglobulin gene, indicating that the CL-1 cells represented a monoclonally expanded population of canine alpha beta T-cell lineage.

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