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Pediatr Neurol. 1997 Nov;17(4):319-21.

Protein C and S deficiency in children with ischemic cerebrovascular accident.

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Division of Neurology, Childrens Hospital Los Angeles, University of Southern California, 90027, USA.


A prothrombotic state caused by a deficiency of protein C or protein S, each an inhibitor of coagulation cascade, increases the risk of ischemic cerebrovascular accident (ICVA) in young adults. This retrospective review studies the relationship of protein C or S deficiency with childhood ICVA. From 1989 to 1995, 37 children were diagnosed by neuroimaging with ICVA unrelated to any known preexisting diagnosis. Protein C deficiency or protein S deficiency was the only identified risk factor for 5.4% (2 patients) and 13.5% (5 patients), respectively, of these 37 children. The data suggest that protein C or protein S deficiency is an important risk factor of ICVA in children.

[Indexed for MEDLINE]

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