Format

Send to

Choose Destination
Curr Opin Struct Biol. 1997 Dec;7(6):849-56.

G proteins, effectors and GAPs: structure and mechanism.

Author information

1
Howard Hughes Medical Institute, University of Texas, Southwestern Medical Center, Dallas 75235-9050, USA. sprang@howie.swmed.edu

Abstract

G proteins from a diverse family of regulatory GTPases which, in the GTP-bound state, bind to and activate downstream effectors. Structures of Ras homologs bound to effector domains have revealed mechanisms by which G proteins couple GTP binding to effector activation and achieve specificity. Complexes between structurally unrelated GTPase-activating proteins with complementary G proteins suggest common mechanisms by which GTP hydrolysis is stimulated via direct interactions with conformationally labile switch regions of the G protein.

PMID:
9434906
DOI:
10.1016/s0959-440x(97)80157-1
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center