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Curr Opin Struct Biol. 1997 Dec;7(6):839-48.

T-cell receptor structure and TCR complexes.

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Department of Molecular Biology, Skaggs Institute for Chemical Biology, Scripps Research Institute, La Jolla, CA 92037, USA.

Erratum in

  • Curr Opin Struct Biol 1998 Feb;8(1):124-5.


The first crystal structures of intact T-cell receptors (TCRs) and their complexes with MHC peptide antigens (pMHC) were reported during the past year, along with those of a single-chain TCR Fv fragment and a beta-chain complexed with two different bacterial superantigens. These structures have shown the similarities and differences in the architecture of the antigen-binding regions of TCRs and antibodies, and how the TCR interacts with pMHC ligands as well as with superantigens.

[Indexed for MEDLINE]

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