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Clin Immunol Immunopathol. 1998 Jan;86(1):3-10.

The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes.

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Department of Medicine, Stanford University School of Medicine, California 94305-5111, USA.


The current paradigm of MHC and disease association is efficient binding of autoantigens by disease-associated MHC molecules leading to a T cell-mediated immune response and resultant autoimmune sequelae. Data presented here offer a different model for this association of MHC with autoimmune diabetes. This new explanation suggests that the association of MHC with autoimmunity results from "altered" thymic selection in which high-affinity self-reactive (potentially autoreactive) T cells escape negative selection. This model offers an explanation for the requirement of homozygous MHC class II expression in NOD mice (and in man) in susceptibility to IDDM.

[Indexed for MEDLINE]

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