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Trends Genet. 1997 Dec;13(12):479-84.

STAR, a gene family involved in signal transduction and activation of RNA.

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Cell and Molecular Biology Institute, University of Texas at Austin 78712-1064, USA.


A new subfamily of KH-domain-containing RNA-binding proteins is encoded by genes that are conserved from yeast to humans. Mutations with interesting developmental phenotypes have been identified in Caenorhabditis elegans, Drosophila and mouse. It is hypothesized that these bifunctional proteins provide a rich source of interesting molecular information about development and define a new cellular pathway that links signal transduction directly to RNA metabolism.

[Indexed for MEDLINE]

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