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Trends Biochem Sci. 1997 Dec;22(12):482-7.

The cyclin box fold: protein recognition in cell-cycle and transcription control.

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1
Oxford Centre for Molecular Sciences, UK.

Abstract

Regulation of both the cell cycle and gene transcription is essential for orderly progression of cell growth and division. Recent results on the structures of two cyclins, cyclin A and cyclin H, and two transcription factor mediator proteins, TFIIB and the A pocket region of the retinoblastoma tumour suppressor protein (Rb), show that they share domains with a strikingly similar alpha-helical topology, despite remote sequence identity.

PMID:
9433129
[Indexed for MEDLINE]
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