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Eur J Pharmacol. 1997 Oct 22;337(2-3):161-4.

Fluoxetine attenuates morphine-induced locomotion and blocks morphine-sensitization.

Author information

1
Biopsychology Section, Clarke Institute of Psychiatry, Toronto, Ontario, Canada. terrence@psych.toronto.edu

Abstract

Repeated morphine treatments result in sensitization, an increase in the efficacy of morphine to stimulate locomotor activity. study examined the effects of increasing serotonin (5-hydroxytryptamine, 5-HT) transmission on morphine-sensitization. For five days rats were administered saline or 5.0 mg/kg fluoxetine prior to treatment with saline or 5.0 mg/kg morphine. Twenty-one days later, rats were tested for their locomotor response to 2.0 mg/kg morphine. Fluoxetine treatment attenuated the locomotor activating effect of acute morphine treatments and blocked the sensitized response to the morphine challenge. These results indicate that increased 5-HT transmission attenuates the locomotor stimulating effects of morphine and prevents the development of morphine-sensitization.

PMID:
9430410
DOI:
10.1016/s0014-2999(97)01308-3
[Indexed for MEDLINE]

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