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Anticancer Res. 1997 Sep-Oct;17(5B):3743-6.

Tumor angiogenesis as a major prognostic factor in stage I lung adenocarcinoma.

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1
Department of Internal Medicine, National Kinki Central Hospital, Osaka, Japan.

Abstract

We investigated the correlation between tumor angiogenesis and prognosis of T1N0M0 lung adenocarcinoma.

MATERIALS AND METHODS:

Forty two specimens resected from patients with T1NOM0 lung adenocarcinoma were investigated by immunohistochemical staining with a monoclonal antibody to CD31. The relationship between microvessel count, clinicopathologic factors and prognosis was studied.

RESULTS:

The microvessel count was significantly higher in cases with vessel invasions than in those without. Univariate analysis showed that microvessel count was related to poorer prognosis. In patients with a high microvessel count (> or = 38), prognosis was significantly poorer than in those with a low count (< 38). Multivariate analysis indicated that the microvessel count and mitosis are prognostic factors in patients with lung cancer, and that the microvessel count is a more important factor than mitosis.

CONCLUSIONS:

Microvessel count may be a major prognostic factor and a useful tool to predict recurrence in patients with T1N0M0 lung adenocarcinoma.

PMID:
9427772
[Indexed for MEDLINE]

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