Format

Send to

Choose Destination
EMBO J. 1998 Jan 2;17(1):181-90.

Xiro, a Xenopus homolog of the Drosophila Iroquois complex genes, controls development at the neural plate.

Author information

1
Laboratorio de Biología del Desarrollo, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile.

Abstract

The Drosophila homeoproteins Ara and Caup are members of a combination of factors (prepattern) that control the highly localized expression of the proneural genes achaete and scute. We have identified two Xenopus homologs of ara and caup, Xiro1 and Xiro2. Similarly to their Drosophila counterparts, they control the expression of proneural genes and, probably as a consequence, the size of the neural plate. Moreover, Xiro1 and Xiro2 are themselves controlled by noggin and retinoic acid and, similarly to ara and caup, they are overexpressed by expression in Xenopus embryos of the Drosophila cubitus interruptus gene. These and other findings suggest the conservation of at least part of the genetic cascade that regulates proneural genes, and the existence in vertebrates of a prepattern of factors important to control the differentiation of the neural plate.

PMID:
9427752
PMCID:
PMC1170369
DOI:
10.1093/emboj/17.1.181
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center