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Chem Biol. 1997 Dec;4(12):885-8.

Protein acetylation: more than chromatin modification to regulate transcription.

Author information

1
Department of Pathology, Beckman Center for Molecular and Genetic Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Abstract

Histone acetyltransferases and deacetylases are involved in the regulation of gene transcription. Recently, tumor suppressor protein p53 has been shown to be a target for transcriptional coactivators that have histone acetyltransferase activity, suggesting acetylation is also involved in the regulation of cell proliferation and tumorigenesis.

PMID:
9427654
DOI:
10.1016/s1074-5521(97)90296-9
[Indexed for MEDLINE]
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