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Curr Biol. 1998 Jan 15;8(2):R49-51.

DNA repair: PARP - another guardian angel?

Author information

1
MRC Cell Mutation Unit, University of Sussex, Brighton, BN1 9RR, UK. p.a.jeggo@sussex.ac.uk

Abstract

Cell lines and mice defective in poly(ADP-ribose) polymerase (PARP) have elevated spontaneous genetic rearrangements and abnormal responses to stresses. These results may be explained by an altered response to damage induced by free radicals, and suggest that PARP limits genomic instability from such damage.

PMID:
9427640
DOI:
10.1016/s0960-9822(98)70032-6
[Indexed for MEDLINE]
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