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Neuroreport. 1997 Dec 1;8(17):3679-83.

A ventral pontine pathway promotes rhythmic activity in the medulla of neonate mice.

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Biologie Fonctionnelle du Neurone, Institut Alfred Fessard, CNRS, Gif-sur-Yvette, France.


We have developed in new-born mice a ventral tilted-horizontal slice preparation for pontine stimulation and recording of spontaneous respiratory-like rhythmic trains of glutamatergic excitatory postsynaptic potentials (EPSPs) in medullary neurons. Electrical stimulations (10-50 Hz for 100-500 ms) of the caudal pontine reticular formation triggered a burst of EPSPs, recycling of the rhythmic activity and persistent increase of the rhythmic behaviour. These results identify a ventral pontine pathway that promotes rhythm generating mechanisms in the medulla and probably derives from a population of lateral reticular neurons identified in the embryonic hindbrain and eliminated after inactivation of the early developmental gene Krox-20.

[Indexed for MEDLINE]

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