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Biol Psychiatry. 1997 Dec 15;42(12):1130-7.

Electroconvulsive therapy increases circadian amplitude and lowers core body temperature in depressed subjects.

Author information

1
Division of Mood and Anxiety Disorders, University of Pennsylvania School of Medicine, Philadelphia, USA.

Abstract

BACKGROUND:

Reduced amplitude of the circadian temperature rhythm and elevated nocturnal body temperature normalize after successful pharmacotherapy of major depression.

METHODS:

Core body temperature was continually monitored in three groups: a) 6 depressed patients before an electroconvulsive therapy (ECT) course and b) after an ECT course; and c) 6 healthy, sex-matched controls of similar age.

RESULTS:

The 24-hour profile of temperature was significantly different in patients pre-ECT than in patients post-ECT or in controls. Post-ECT subjects and controls manifested 24-hour profiles similar to one another. Circadian temperature rhythm amplitude increased after ECT. The mean asleep and mean 24-hour temperatures were significantly higher in patients pre-ECT than post-ECT and controls.

CONCLUSIONS:

We find that ECT restores a disrupted circadian temperature rhythm in depressed patients.

PMID:
9426883
DOI:
10.1016/s0006-3223(97)00046-2
[Indexed for MEDLINE]

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