Format

Send to

Choose Destination
Curr Opin Cell Biol. 1997 Dec;9(6):807-14.

Coupling cell division and cell death to microtubule dynamics.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02138-4307, USA.

Abstract

The mitotic spindle is a self-organizing structure that is constructed primarily from microtubules. Among the most important spindle microtubules are those that bind to kinetochores and form the fibers along which chromosomes move. Chemotherapeutics such as taxol and the vinca alkaloids perturb kinetochore-microtubule attachment and disrupt chromosome segregation. This activates a checkpoint pathway that delays cell cycle progression and induces programmed cell death. Recent work has identified at least four mammalian spindle assembly checkpoint proteins.

PMID:
9425345
DOI:
10.1016/s0955-0674(97)80081-6
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center