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Curr Opin Cell Biol. 1997 Dec;9(6):773-81.

Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression.

Author information

1
Department of Biological Chemistry, School of Medicine, University of California at Los Angeles 90095, USA. zavitz@hhmi.ucla.edu

Abstract

Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.

PMID:
9425341
[Indexed for MEDLINE]

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