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Curr Opin Cell Biol. 1997 Dec;9(6):773-81.

Controlling cell proliferation in differentiating tissues: genetic analysis of negative regulators of G1-->S-phase progression.

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Department of Biological Chemistry, School of Medicine, University of California at Los Angeles 90095, USA.


Withdrawal from the cell cycle as cells begin to differentiate is accomplished by the downregulation of cyclin-dependent kinase activities in G1 phase. Recent analysis of loss-of-function mutations in flies, worms, and mice has provided insight into the roles of various negative regulators of G1 phase in developing organisms.

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